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25 Clinical manifestations Neurological symptoms in WD typically begin in the second or third decade

101 In rats with tail or foot amputation, and heparin, warfarin and aspirin application, without 62 or with nitric oxide (NO)-agents, NO synthase (NOS)-blocker N-nitro-L-arginine methyl ester (L-NAME) or NOS-substrate L-arginine, 63 prolonged bleeding and thrombocytopenia were counteracted

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[72] The potential causes include contamination with toxic alkaloids from kava leaves and stems, differences in traditional versus commercial preparations, drug interactions affecting liver enzymes, and genetic variations in metabolism among populations