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However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)

Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative

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This sample size is consistent with prior mechanistic studies and the 3R principles [52, 53], although the relatively small cohort remains a limitation and should be expanded in future work