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Two independent reviewers extracted the data and assessed the methodological quality of included studies

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Specifically, the hypoxic synovial milieu initially induces lipid synthesis in T cells, and this metabolic reprogramming in turn drives pathogenic T cell phenotypes and enhances tissue infiltration capacity

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Most of these studies have been on animals, so there is more research needed on humans

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Through mucus protein degradation, Akkermansia has beneficial effects on the gut barrier (210)

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& Wagner, A

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