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doi: 10.3389/fphar.2023.1222195 Received 14 May 2023 Accepted 26 June 2023 Published 18 July 2023 Volume 14 - 2023 Edited by Wirginia Kukula-Koch, Medical University of Lublin, Poland Reviewed by Armando Caceres, Galileo University, Guatemala Laiba Arshad, Forman Christian College, Pakistan Poonam Arora, Shree Guru Gobind Singh Tricentenary University, India Updates Copyright 2023 Yuandani, Jantan, Haque, Rohani, Nugraha, Salim, Septama, Juwita, Khairunnisa, Nasution, Utami and Ibrahim

For example, a meta-analysis of 18 RCTs that included 74,498 individuals found that supplements containing B vitamins, including 20 to 2,000 mcg/day vitamin B12, had little or no effect on cancer incidence, cancer deaths, or all-cause mortality during follow-up periods of 2 to 7.3 years [70]

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