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Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway

J Lipid Res (2006) 47(9):19409

Inform patients and caregivers of this potential interaction, educate them on the signs and symptoms of respiratory depression (including sedation)

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