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The authors acknowledge additional financial support from the UK Department of Health and Cancer Research UK via Experimental Cancer Medicine Center awards to Kings Health Partners/Guys & St Thomas NHS Foundation Trust (JS)

Individuals with risk factors for delayed healing represent the primary group of interest

In this protocol, we favor a functional definition of SLP dependency as the comparatively limited capacity of malignant cells to sustain long-term proliferation when forced to use OXPHOS-exclusive metabolism (e.g., deprivation of glucose and glutamine, the two primary SLP fuels, at the substrate, transport, or utilization level)

doi: 10.1136/ard-2024-225645 106 WangTZhaoXLiJYinCJiangBXieJet al

Signal transducer and activator of transcription 3 (STAT3) binds to DNA response elements in the promoters of ferroptosis-related genes (FTH1, SLC7A11, and GPX4) and regulates their expression