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Testosterone enhances muscle mass by directly stimulating muscle growth through the activation of the androgen receptor, while inhibiting the catabolic pathway of the ubiquitin-proteasome system (105, 108, 109)

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Homocysteine levels were also correlated with obesity, smoking, defects in the MTHFR gene, and deficiencies of vitamin B12 and folate.23 Evidence from clinical trials for the beneficial role of a regimen of supplemental folate, vitamin B6, and vitamin B12 on CVD risk is lacking