igf-1 lr3 half life pharmacokinetics Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit Late-life targeting of the IGF-1

Abbreviations ABC: ATP-binding cassette ADM: Adrenomedullin ADC: Antibodydrug conjugate APC: Antigen presenting cell CAF: Cancer-associated fibroblast CBP: Carboplatin CSC: Cancer stem cell DDR: DNA damage response DFS: Disease-free survival DTP: Drug-tolerant persister ECM: Extracellular matrix EMT: Epithelialmesenchymal transition EOC: Epithelial ovarian cancer FTE: Fallopian tube epithelium GSH: Glutathione GST: Glutathione-S-transferase HGSOC: High-grade serous ovarian cancer HRR: Homologous recombination repair IMC: Imaging mass cytometry MC: Mesothelial cell MMR: Mismatch repair MT: Metallothionein NER: Nucleotide excision repair OXPHOS: Oxidative phosphorylation PARP: Poly(ADP-ribose) polymerase PDO: Patient-derived organoid PFS: Progression-free survival PUFA: Polyunsaturated fatty acid scRNA-seq: Single-cell RNA sequencing TAM: Tumor-associated macrophage TEC: Tumor endothelial cell TME: Tumor microenvironment TSP: Tumorstroma proportion References Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY

NK/T cell lymphoma) or high heterogeneity among the sites of the disease and immune compartment (e.g

SIRT3, found mainly in mitochondria, stops the NLRP3 inflammasome by deacetylating and activating mitochondrial superoxide dismutase SOD2 [14]

"Intelligent testing Page 220 and 221: Ikegawa S, Hasegawa M, Okihara R, S Page 222 and 223: Page 224 and 225: Iversen A, Kuhn I, Franklin A, and Page 226 and 227: Jang Y-C, Lee C, Yoon O-S, and Kim Page 228 and 229: Chemosphere 2003, 50(3):437-443

The exhaustion of hepatic GSH was also observed in diosbulbin B treated animals (Figure 2)