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Apart from delivering the Se from the liver to other parts of the body, it also exerts enzymatic antioxidant (peroxidase) activity in plasma, notably against peroxynitrite-mediated oxidation, nitration, and nitrosation (7779), and against lipid hydroperoxides formed by lipoxygenases and cyclooxygenases, thus protecting circulating lipoproteins (phospholipids) and cholesterol from oxidation (57, 8082)

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While numerous studies reported an association between vitamin B 12 deficiency and metformin treatment, in 2017, Rodrguez-Gutirrez et al., found no variation in vitamin B 12 levels between participants receiving metformin and those naive to therapy [53]

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