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According to researchers who have had access to some of the data, the first randomized clinical trial with AOD 9604 reported up to 2.6 kg of weight loss in obese individuals

This removes any ambiguity about when the medication needs to be replaced

Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself

This is a compound that shifts systemic methylation balance and NAD+ economy, and nobody has published what that looks like in humans over months or years

PMID: 38987173 bioRxiv Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss