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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

The invention provides an embodiment which provides a sustained concentration of copper peptide in vivo of 12 + 2 meg/ml over 24 hrs from the time of administration

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There are two main ways to avoid excessive interaction of the gut microbiota with TLRs to prevent activation of the intestinal and in some cases systemic immune response: i) decreasing the expression of TLRs, and ii) moving TLRs from the plasma membrane into lysosomes (Semin et al., 2021)