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These models have been updated (e.g., PETROTOX) from the first models developed (French-McCay, 2002)

System Xc-passes through a heterodimer of the light-chain subunit SLC7A11 and the heavy-chain subunit SLC3A2, and glutamate-cysteine ligase (GCL) and glutathione synthase (GSS) transfer cystine to the cell and synthesise glutathione (GSH)

Amyloid-forming segment induces aggregation of FUS-LC domain from phase separation modulated by site-specific phosphorylation

How TCM interferes with autophagy to improve DCM is a promising research direction and may also be one of the focuses of future research work

This lets tissue expand gradually rather than forcing fluid in and causing micro-tears