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Bitter orange decoctions have been shown to elevate cyclosporine blood levels toxically in pigs, and in vitro studies have demonstrated that it inhibits human CYP-450 3A (CYP3A), potentially affecting the metabolism of drugs processed by this enzyme

For the measurement of tumor growth over time, statistical significance was determined using two-way ANOVA or multiple t-test

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While multiple organs contribute to detoxification, the liver serves as the primary metabolic hub

Supplementary Table 2 contains the specific oligonucleotide sequences