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Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis

By activating the AMPK pathway, MOTS-C helps regulate energy balance and improve overall metabolic function

[Abstract]2023 Jun:62:102702

Br J Dermatol 155(3):515521

Intermembrane proteins released from mitochondria through Bax/Bid pores, e.g., apoptosis inducing factor (AIF) and endonuclease G, translocate to the nucleus and cause DNA fragmentation [53]