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154 In addition, elevated levels of serum Cu have been correlated with both tumor stage and disease progression in patients with colorectal, lung, and breast cancer

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For example, FuA GST dimeric arrangement is close to the one observed in the canonical dimer in that their C2 axis is along the same direction (Figure S1A)

Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences

PMID 15149073