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Normally, the kidney and liver rely heavily on oxidative phosphorylation for energy production as both the liver and the kidney are dense with mitochondria

2), S38S51 (2008)

Remarkably, it achieves this without inducing systemic growth-promoting effects or negatively impacting insulin sensitivitya critical safety advantage over administering the full hormone

The two dont have to be mutually exclusive, but any peptide therapy in this context needs to account for the full hormonal picture, thyroid, cortisol, estrogen, not just body weight

A clinical trial demonstrated that oral sodium selenate supplementation increases brain Se levels without notable side effects, and participants with improved Se levels do not exhibit worsening Mini-Mental State Examination scores over time (108)