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On the one hand, this increases the options for therapeutic interventions, but on the other hand, it makes it even more difficult to selectively target single receptors to yield neuroprotection (Figure 3) [43]

It refers to the process by which cancer cells reshape their metabolic networks through alterations in gene expression and signaling pathways to meet the bioenergetic and biosynthetic demands of rapid proliferation [15]

(2019) 63:e0268918

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Importantly, it is well documented that phosphorylation could contribute and enhance tau polymerization (194)