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A comparison between the water-soluble glucagon receptor monoagonist glucagon CEX (Gcg CEX) and the GLP-1R mono-agonist exendin-4 at 1 mol/kg/day in diet-induced obesity mice demonstrated nearly equivalent degrees of body weight loss and improvements in glucose metabolism, both without signs of fasting hyperglycemia [9]

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KarikKMuramatsuHWelshFALudwigJKatoHAkiraSet alIncorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability