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MELAXIN Astaxanthin Extra Whitening Ampoule use in the morning and/or evening on clean, toner-dampened skin of the face and neck: dispense 23 drops, spread evenly and gently pat in until fully absorbed, then continue your usual routine by applying a moisturizing cream

Mechanistically, peroxynitrite has been shown to have 2 distinct mechanisms of action in its interaction with NOS: it can either uncouple the enzyme by oxidation of bound BH 4 or abolish enzymatic function by oxidative destruction of the NOS heme site, thus rendering an inactive enzyme, as opposed to one that is uncoupled 49,50

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10.1007/s00018-017-2595-9 28

A randomized controlled trial of topical GHK-Cu cream for facial rejuvenation in postmenopausal women