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There was a 1.4-fold decrease for HEK-293 cells and a 1.1-fold decrease for K-562 cells in total glutathione levels at 25M of menadione compared to the vehicle control

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In conclusion, the experimental data are well described by the model for all knock-downs, except for slight deviations for siKEAP1, where the increase in Keap1-GFP and Srxn1-GFP after DEM exposure was underestimated by the model

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