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The mechanism of action of IGF-1 LR3 is multifaceted, involving the direct stimulation of muscle cells and other tissues by binding to the IGF-1 receptor, which activates intracellular signaling pathways essential for muscle growth and differentiation

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All subjects were enrolled in a standard wound care protocol, where only the subjects with sharp ulcer wound or debridement were entered into this randomized, placebo controlled clinical trial

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