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En parallle d'un rgime hypocalorique et d'un programme de 150 minutes de marche hebdomadaires, sept participantes spares en deux groupes ont appliqu quotidiennement le soin ou un placebo pendant 28 jours

Generally, linkers containing Val-Cit or Val-Ala sequences are most widely employed due to high stability in human plasma and efficient drug release toward the lysosomes of target cells