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Loss of extracellular matrix is in part due to death of fibrous cap smooth muscle cells, resulting from macrophage-derived Fas receptor ligand (195), inflammatory cytokines (196), and oxidation products (Figure 5) (197,198)

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When the production of ROS exceeds the counteracting mechanisms of the antioxidant system, oxidative stress will occur, resulting in oxidative damage to proteins, nucleic acids and lipids, affecting the normal functioning of the body and inducing the occurrence of various diseases such as NDs 22 , 24

Elevated concentrations of free radicals in the central nervous system (CNS) significantly influence the pathophysiology and progression of neurodegenerative and inflammatory processes [1]

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