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identified a reversible chromatin-mediated tolerant state that allowed cancer cells to survive exposure to lethal doses of EGFR inhibitors, introducing the concept of drug-tolerant persister (DTP) cells ( The conceptualization of DTP cells was strengthened by their close analogy to bacterial persistence

While neurosurgical interventions (e.g., lesioning, Deep Brain Stimulation) can alleviate symptoms, they involve irreversible neuronal damage (4)

British Journal of Dermatology (2004)

Indeed, substrates modified with either K11/K48 or K11/K48/K63 branched chains preferentially associate with the proteasome 3,8

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