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Semaglutide is a medication that mimics a natural hormone in the body called GLP-1

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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

Because of the eects of vitamin B12 on pregnancy are based multiplied by 10, it is possible that the eects of vitamin B12 on dierent groups may be masked in the absence of sucient data, thus, explains why there is no statistically signicant dierence in pregnancy rates between groups in terms of pregnancy rates alone