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Lonsdale R, Hoyle S, Grey DT, Ridder L, Mulholland AJ

Collectively, these Pharmacophore characteristics support the hypothesis that NAC can act as a molecular stabilizer, counteracting Crystallin unfolding and aggregation processes that drive age-related lens opacity, thereby positioning NAC as a promising therapeutic candidate for anti-cataract intervention 106

Given the significant reduction in intracellular GSH, and induction of its canonically partnering stress response, we asked whether this impacted intracellular selenoprotein abundance in the CNS

For example, HIF1 inhibitors may overcome hypoxia-induced resistance by blocking BNIP3L-mediated mitophagy ( 2.4.2 Potential of combination therapy strategies Combination therapy strategies have emerged as a promising avenue in overcoming resistance

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