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In other words, berberine suppressed A production via inhibiting protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/eukaryotic translation-initiation factor 2 (elF2) signaling-mediated BACE1 translation (Liang et al., 2021)

Disser NP, Sugg KB, Talarek JR, Sarver DC, Rourke BJ, Mendias CL

Nigella sativa : a potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus

It is noteworthy that ferroptosis and inflammation do not represent a unidirectional causal relationship, but rather form a bidirectional positive feedback loop