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X.et al (2020c)

Variations in binding kinetics and effects on action potential duration divide Class I drugs into three categories (11): Class IA : Moderate sodium channel blockade

Many anticancer drugs induce oxidative damage as the primary mechanism through which to kill cancer cells, and the reduced capacity for ROS production under hypoxic conditions reduces the efficacy of these drugs (175), likely mediated by the downregulation of oxidative phosphorylation (OXPHOS) by HIF-1 (176)