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doi: 10.1016/j.cellimm.2007.04.005 115 HuangHFChenPLuRLinZXWuYChenYZ

CHE exerts antitumor activity by possessing a solid affinity for inhibiting the telomerase activity by substrate sequestration through G-quadruplex stabilization, which leads to fast proliferation of cells, thus promoting tumor cell death (Noureini et al., 2017)

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This discrepancy might be related to the limited capacity of ECs to produce IFN- upon STING activation, but it could also be due to the requirement of IFN--mediated IRF7 upregulation for IFN- expression [131]