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10.3892/mmr.2014.2842 15 MaddalenaL

Pushing through excessive fatigue during aggressive fat loss protocols leads to overtraining syndrome, which actually increases muscle catabolism and slows fat loss

Since the pathways involved in mitochondrial metabolism, calcium buffering, mitochondrial dynamic (mitochondrial trafficking through the axons, mitophagy, fusion and fission), regulation of apoptosis and oxidative stress are essential to an adequate differentiation, development and maturation of CNS, the recapitulation of all these processes in brain organoids is a major challenge

At the same time, studies could also aim to validate the associations between these SNPs and micronutrient levels in the general population to ensure their consistency across different populations

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