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Description

The pKa values of amino groups are much higher, with values ranging from 9 to 10.5

Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications

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This was almost completely lost in mutants targeting the PL motif, Leu1204 (DENND4C(L1204A) and -(L1204D)), and significantly reduced by targeting the secondary site through deletion of the short -helix (residues 12321243) or targeted mutagenesis of Tyr1239 (Fig