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Interleukin 13 receptor alpha 2 (IL13R2): Expression, signaling pathways and therapeutic applications in cancer

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PPAR-alpha activation may antagonize these undesirable pro-inflammatory activities: Studies in streptozotocin (STZ) mice (a murine model of type 1 diabetes) have documented prevention of pericyte loss in their retinas with fenofibrate treatment [29]

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For instance, insulin-stimulated hepatocytes display a short-lived ROS burst (mainly HO), which transiently inhibits protein tyrosine phosphatases, thereby enhancing insulin-receptor autophosphorylation and downstream signaling