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However, sodium overload can be a concern with SPS

doi: 10.1016/j.isci.2022.105911 274 LiuLYYangTJiJWenQMorganAAJinBet al

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Notably, while excess iodine is well known to trigger thyroid autoimmunity in susceptible individuals, evidence from the literature is reassuring that an adequate iodine status (defined as a UIC between 100 g/L and 299 g/L) is safe in this regard [25, 26]