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In parallel, vectors consisting of adeno-associated viruses (AAV) provide a gene therapy-based approach for sustained, localized expression of neurotrophic factors in target brain regions [243, 244]

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Thus, we decided to study its effects on both parental (sensitive) BT474 cells and on derived cells, made resistant to TZ by the continuous exposure to high doses of therapeutic antibody [BT474-R], leveraging several different in vitro models, including systems generated with the 3D bioprinting technology to achieve more reliable preclinical models

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three brothers, Charles, Robert, and Sam Brown, Jr