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Future prospects and challenges Although osteoporosis therapies targeting innate immunity have advanced, core challenges remain: First, insufficient target specificitymany drugs (e.g., TNF- antagonists, C5aR1 antagonists) may impair normal immunity and bone metabolism (e.g., TNF- inhibition delays fracture healing, while C5aR1 antagonists induce cardiovascular side effects), necessitating the development of bone tissue- or cell-specific drugs

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Control of human viral infections by natural killer cells