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Further compounded by the lack of energy consumed to offset the expenditure, it creates a calorie deficit influencing thyroid hormone regulation with transporters, slowing down metabolism systemically with leptin and estrogen signalling disturbed, alteration with iron absorption and loss = inducing menstruation issues such as amenorrhea

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Under stress conditions, p53 activation involves the phosphorylation of many N-terminal serine and threonine residues by distinct protein kinases

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2008;72(Pt 4):47884