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These oxidation and rearrangement processes, followed by further dehydration and fragmentation of product, promote the formation of advanced glycation end products (AGEs) (Figure 4) and generate other compounds with chemically active carbonyl groups

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Therefore, consistent with the ssGSEA revealing the correlation between glycine and immune cells, glutathione metabolism significantly correlated with lymphocytes, indicating that glycine could play an important role in the immune reaction related to the resistance response of multiple myeloma patients to pomalidomide

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