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Evidence suggests that increasing vitamin B12 levels in patients with deficiencies with high-dose oral supplementation at 1000mcg is a successful tactic

Heffernan et al., Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment, Int

High-dose oral vitamin B12 supplements (1000-2000 micrograms per day) have also been shown to raise levels, because high doses can usually compensate for the bodys poor absorption

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