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The foundation of gas therapy stems from the landmark discovery of NO as the first endogenous gaseous mediator, recognized by the 1998 Nobel Prize in Physiology or Medicine for its cardiovascular therapeutic implications

The next day, output titres were calculated according to the equation: Cfu/mL = [No

134 Since the initial inflammatory phase is crucial for bone repair, the circadian clocks control over neutrophil activity and aging presents a novel temporal mechanism that could affect the efficiency of bone regeneration