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As many cysteine-containing proteins (transporters, receptors and enzymes) at extracellular surfaces or in extracellular fluids are prone to oxidation, their activity might be influenced by the thiol/disulphide redox microenvironment

Rheumatology 61 , 47974808 (2022)

10.1007/s00210-024-03625-3 118 JouJ.GabdankI.LuoY.LinK.SudP.MyersZ.et al (2019)

Malondialdehyde and thiobarbituric acid-reactive substances have also been detected in urine, plasma, sputum, and BAL fluid in relation to the severity of asthma 37,38

Mitochondrial dysfunction in ASD is further supported by the presence of non-specific biomarkers including reduction in carnitine and increases in lactate, pyruvate, creatine kinase, aspartate aminotransferase and alanine aminotransferase compared to control groups (Frye, 2020