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7 , 1214 , 21 In particular, drugs absorbed in the maxillary and ophthalmic nerve branches can be delivered to the brainstem via the pons, allowing the potential for brain-targeted delivery

Mechanistic studies have linked celastrols protective effects to pathways such as the reduction in HO-1-mediated autophagy and the SIRT1-mediated inhibition of the EZH2-related Wnt/-catenin pathway [22, 39]