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Current Food and Drug Administration (FDA)-approved treatments, including cholinesterase inhibitors, N-Methyl-D-aspartic acid (NMDA) receptor antagonists, and monoclonal antibodies, provide only modest symptomatic relief or partial disease modification

It is called glucotoxicity previously, 126 however, we may call this phenomenon hyperglucotoxicity, as a normal glucose level is not toxic to islet cells

Oxygen consumption was expressed as nanoatoms O 2 per minute per milligram of cells