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Consequently, attention has turned toward dietary bioactive compoundsparticularly (poly) phenolsas promising alternatives owing to their multitargeted biological activities and favorable safety profiles ( Among dietary (poly) phenols, EC, a cis-configured flavan-3-ol abundant in tea, cocoa, apples, and berries, has emerged as a notable candidate due to its distinctive chemical properties and biological activities

Metabolic and redox adaptations supporting this response were assessed by analyzing oxidative pentose phosphate pathway (oxPPP) activity, glutathione-dependent antioxidant systems, and mitochondrial oxidative phosphorylation in MPLA-primed macrophages

We often think about longevity in terms of diet, weight, or cardiovascular fitness

The model is that changing from one type to another is a consequence of overexpression of the "master" gene inhibiting another