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Selenium is an integral part of GSH peroxidase, the enzyme that mediates antioxidants by glutathione (Parantainen et al

doi: 10.1038/ncpendmet0424 38 ShahidMAAshrafMASharmaS

They also identified proteins associated with the extracellular matrix including cytokines, fibronectin, tenascin, and OPN

Iglesias et al., 2004

As a result, it causes immune-mediated enteropathy, intestinal inflammation, followed by the atrophy of villi, crypt hyperplasia and increased infiltration by intraepithelial lymphocytes [11]