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A., Lin, C.-F., Chen, C.-H

However, the growing awareness of interactions between glutathi- one and TRX systems (Michelet et al., 2005

(2012) speculated that a reduction in ATP could be due to oxidative stress and that the increased levels of subunits of OXPHOS complexes were compensatory

doi: 10.1016/j.brainresbull.2021.10.007 58 MitraSNatarajanRZiedonisDFanX

Hemolysis: heme and iron release Repeated cycles of sickling/unsickling lead to the fragilization of the RBC membrane and thus to hemolysis that results in the release of extracellular hemoglobin, free heme, and free iron, all highly toxic to the vasculature by triggering vascular oxidative burden [22,137,138]