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Chronic ethanol consumption has also been shown to cause reduced expression of TET1, and the resulting decrease in DNA hydroxymethylation can contribute to hepatocyte apoptosis, ALD progression, and the development of hepatocellular carcinoma (HCC) (3032)

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Enhances mitochondrial function for overall cellular vitality

MSC-EVs function predominantly by the activation of autophagy via the catalase enzyme, the Nrf2 signalling pathway, the miR 146a-inhibited NF-B pathway, and the targeting of the PTEN-PI3 K/Akt pathway by miR-223 (145)