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Summary of Findings and Certainty of Evidence (GRADE Assessment) This systematic review included seven studies assessing the effect of dextrose prolotherapy on CLBP, covering multiple outcomes such as pain intensity, functional disability, quality of life, walking distance, and pain-related daily activity impact

GABAergic and Monoaminergic Pathway Analysis Research indicates DSIP may influence GABAergic tone and monoamine oxidase (MAO-A) activity, potentially impacting serotonin and dopamine metabolism

Across these studies, CQD uptake, cytotoxicity, and organ accumulation are strongly influenced by surface chemistry and dose

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