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Pirfenidone, a Food and Drug Administration (FDA)-approved medication for IPF, attenuates pulmonary function decline by targeting the TGF- signaling pathway and exhibits neuroprotective effects by mitigating neuroinflammation and neurodegeneration following traumatic brain injury (TBI) [85, 86]

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Natural opioids, semi-synthetic opioids made from natural opioids, and synthetic opioids created in a lab are all called opioids

This is likely due to the crucial role of TNF-, and other cytokines, in host response against Mtb

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