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It can also interact with reduced oxygen species to form hydroxyl radical that inactivates enzymes and disrupts the membranes and organelles 44

Although NADPH is unable to translocate to the mitochondria across the inner membrane, its exchange between the cytosol and mitochondria is achieved by NADPH shuttle functions through the enzymes isocitrate dehydrogenase 1, [NADP +] (IDH1), and isocitrate dehydrogenase [NADP] mitochondrial (IDH2) (White et al

placebo in older adults and those results will be forthcoming soon. Premranjan Kumar, Chun Liu, Jean Hsu, Shaji Chacko, Charles Minard and Farook Jahoor, all at Baylor College of Medicine, contributed to this work

6 Previous studies proposed the role of reactive metabolites in methimazole-induced toxicity

Inhibition of acetate and propionate assimilation by itaconate via propionyl-CoA carboxylase in isocitrate lyase-negative purple bacterium Rhodospirillum rubrum