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26 Studies have demonstrated that arginine and lysine amino acid substitution in peptides favorably facilitate insertion into bacteria membrane due to their positive charge interacting with bacterial membrane, while the presence of hydrophobic amino acids such as tryptophan and phenylalanine within peptide sequences are associated intensified antimicrobial activity against bacteria

Zhang W, Chen L, Xiong Y, Panayi AC, Abududilibaier A, Hu Y, et al

Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells

Thus, disruption of the intestinal flora can cause intestinal inflammation, which spreads to the lungs